Champions League Round of 16: Fixtures, Top Betting Odds & Predictions
This is it, folks. The plot thickens with 16 teams left to fight their way to the UEFA Champions League finals. Although lacking the usual suspects like Juventus, AC Milan, or Man City, the 2025 Champions League round of 16 match-ups are some of the best we’ve seen in years.
The football fan in me just wants to sit back, relax, and enjoy every minute of every game I could catch live. But the bettor in me cannot help but notice that the round of 16 odds are especially generous this time round, with the likes of BC.Game, Stake, and Playbet.io giving me plenty to think about.
Let’s unpack the 2025 UCL round of 16 fixtures, check out the most competitive odds for each market, and make a few bold predictions while we’re at it.
Champions League Round of 16 Dates
The round of 16 Champions League is slated for March 4 and 5, with the respective returning legs to be played a week later (March 11 and 12). Further down the line, the finals will be played on May 31, 2025, at the Allianz Arena.
Round of 16 Champions League Fixtures
We’ve had our fair share of titan clashes and surprise exits thanks to the new UCL format. The fortune has pitted favourites like Man City and Real Madrid in the earlier round, with Pep’s side repeating the Premier League form and falling way short. Likewise, PSV proved too much for the Old Lady, while AC Milan couldn’t deal with Feyenoord on the day.
That leaves us with a round of 16 looking as follows:
- Club Brugge vs Aston Villa
- Borrussia Dortmund vs Lille
- PSV Eindhoven vs Arsenal
- Real Madrid vs Atletico Madrid
- Feyenoord vs Inter
- Bayern Munich vs Bayer Leverkusen
- Benfica vs Barcelona
- Paris Saint-Germain vs Liverpool
Let’s tackle the four most exciting match-ups in more detail, shall we?
Real Madrid vs Atletico Madrid
The Derbi Madrileño is probably the most eye-catching fixture of this round. Los Blancos, with 14 UCL titles under their belt, are facing the city rivals famed for their resilience and street-wise know-how. Stake seems to have the best odds for this one, so do check it out.
Benfica vs Barcelona
If their group-stage games are anything to go by, expect goals galore at this one. Especially at Estádio da Luz, where it ended 4:5 in favour of the visitors last time around. Still, if you’re interested in playing singles, you’re going to love the wild.io odds here.
Bayern Munich vs Bayer Leverkusen
The Bundesliga battle royale isn’t just another clash between German giants. It’s the way to either confirm last year’s coup or, for Bayern, to remind the world who the top dog is. Odds-wise, Jackbit and ybets are paying a lot of attention to this game.
Paris Saint-Germain vs Liverpool
Both teams are known for their expanding, attacking football, and goals seem imminent. According to bookmakers, Liverpool is the favourite to go through, but looking at Metaspins and BC.Game odds, Les Parisiens just edge it for the first leg.
UEFA Champions League Predictions
Now, we get to the fun part. The odds for the UCL round of 16 are already out, and I can freely flex my predictive muscles and try giving you some betting tips.
Let's start at the Derbi Madrileño, where I can see Real Madrid bouncing back from the Betis slump and winning the first leg. Stake and RakeBit are especially generous with odds of 1.93 on Real Madrid. The same odds are echoed by Jackbit.
I expect goals at both Parc des Princes and Estádio da Luz; my choice of bookmakers would be Playbet.io (1.8 for over 3 goals and 2.01 for over 3.5 goals, respectively). Also, I'll be bold enough to predict the score for Paris Saint-Germain vs Liverpool and that's 2:2 in the first leg (8.0 at Playbet.io).
Arsenal is playing to save the season, and I can't see anything else than the Gunners powering through PSV. However, not at the Philips Stadion. Mikel Arteta's side lacks attacking options, and a draw or a minimal PSV win seems likely. BC.Game is giving the draw a generous 3.5.
Borussia Dortmund vs Lille and Feyenoord vs Inter seem like foregone conclusions, with Borussia and Inter Milan likely to win both legs. Conversely, Club Brugge vs Aston Villa is probably the most unpredictable Champions League round of 16 pair, but given Emery's stature as the master of cup football, I can see only one winner there.
Last but far from least, I can see the Bundesliga derby swaying either way. But given that Bayern Munich knows no victory in their last 6 fixtures, I'm willing to give the nod to Leverkusen to qualify and use ybets generous offer of 2.40. Not in the first leg, though. I'd go for a draw or a minimal Bayern win.
The Odds Are in Your Favour
The 2025 Champions League round of 16 brings some cracking fixtures. The novelty of the new UCL format has worn off and now we’re at the well-known turf where one dribble or one mistake can be a deciding factor. The odds reflect the unpredictable nature of these games, and I urge you to check them out.
Milos Antic
Sports Betting Expert
Milos is a sports betting professional whose special skill involves sitting through countless hours of football fixtures. He entered the sports betting arena in 2017 and hasn't looked back since. He is that guy who gets stopped and asked for a handy betting tip or two. As an in-house betting expert for CryptoGamba, Milos takes much pride when results go the way he called them while always finding a fitting excuse when they don't.
